The University area of the City of Irvine is bordered by the San Diego Freeway (I-405) on the north, Laguna Canyon Road (I-133) on the east, the San Joaquin Hills Transportation Corridor (SR 73) on the south.This area includes the communities of Rancho San Joaquin, Turtle Rock, University Park, University Town Center, Quail Hill, Shady canyon and Turtle Ridge.

The University area also includes the Irvine Business Complex (IBC), which is bordered by the San Diego Creek on the east, Barranca Parkway on the north, The Newport Freeway (I-55) on the west and MacArthur Blvd. on the south.This area of the city includes both commercial and residential areas.